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In 2025, the European Medicines Agency reviewed the evidence and concluded that NAION a type of sudden, usually permanent vision loss is a very rare side effect of semaglutide

This guidance applies to compounded semaglutide and other prescribed GLP-1 medications

ACS Med Chem Lett 8:560565

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Wegovy is indicated for people ages 12 years and older who have: A BMI of 30 kg/m 2 or higher A BMI of 27 kg/m 2 to 29.9 kg/m 2 and at least one weight-related comorbidity , such as high blood pressure, type 2 diabetes, or obstructive sleep apnea Wegovy is also indicated to reduce the risk of major cardiovascular events , such as heart attack or stroke, in people who have obesity or overweight